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Docetaxel for the post-surgery treatment of patients with node-positive breast cancer

机译：多西紫杉醇用于淋巴结阳性乳腺癌患者的术后治疗

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Adjuvant chemotherapy reduces risk of relapse and cancer-related mortality in early stage breast cancer. Over the last decade, taxanes (paclitaxel and docetaxel) have been incorporated into various adjuvant trials and have demonstrated a significant benefit in the management of early stage breast cancer. Clinical trials using combinations of taxanes with targeted therapy have also shown considerable activity in breast cancer. This article reviews the pharmacology of docetaxel, a semi-synthetic taxane, and the clinical trials supporting its use in patients with node-positive breast cancer.

机译：辅助化疗可降低早期乳腺癌的复发风险和与癌症相关的死亡率。在过去的十年中，紫杉烷类药物（紫杉醇和多西紫杉醇）已被纳入各种辅助试验中，并显示出在早期乳腺癌治疗中的显着益处。紫杉烷类药物与靶向治疗相结合的临床试验也显示了在乳腺癌中的相当大的活性。本文综述了半合成紫杉烷多西紫杉醇的药理学，以及支持其在淋巴结阳性乳腺癌患者中使用的临床试验。

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Pant, Shubham; Chilukuri, Meena P; Ramaswamy, Bhuvaneswari;
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年度 2008
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原文格式 PDF
正文语种 {"code":"en","name":"English","id":9}
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专利

1. Docetaxel for the post-surgery treatment of patients with node-positive breast cancer [J] . Shubham Pant, Meena P Chilukuri, Bhuvaneswari Ramaswamy Therapeutics and Clinical Risk Management . 2008,第2期

机译：多西紫杉醇用于淋巴结阳性乳腺癌患者的术后治疗
2. Bi-weekly docetaxel in the adjuvant treatment of node-positive or high-risk breast cancer patients: phase I study of the Shiga Breast Cancer Study Group [J] . Hajime Abe, Hiroki Ogawa, Takashi Okino, Breast Cancer . 2009,第1期

机译：双周多西紫杉醇在淋巴结阳性或高风险乳腺癌患者的辅助治疗中：滋贺乳腺癌研究组的I期研究
3. Phase III study of doxorubicin/cyclophosphamide with concomitant versus sequential docetaxel as adjuvant treatment in patients with human epidermal growth factor receptor 2-normal, node-positive breast cancer: BCIRG-005 trial. [J] . Eiermann W, Pienkowski T, Crown J, Journal of Clinical Oncology . 2011,第29期

机译：阿霉素/环磷酰胺与人用表皮生长因子受体2-正常，淋巴结阳性乳腺癌患者同时或顺序多西他赛作为辅助治疗的III期研究：BCIRG-005试验。
4. Breast MRI radiomics for the pre-treatment prediction of response to neoadjuvant chemotherapy in node-positive breast cancer patients [C] . Karen Drukker, Iman El-Bawab, Alexandra Edwards, SPIE Conference on Computer-Aided Diagnosis . 2019

机译：乳腺MRI辐射射清，用于节点阳性乳腺癌患者对新辅助化疗的反应预处理预测
5. Reducing stress in breast cancer patients: The effects of a mindfulness-based stress reduction program on measures of stress and mood in post-treatment early stage breast cancer outpatients [D] . Mackenzie, Michael 2003

机译：减轻乳腺癌患者的压力：基于正念的压力减轻程序对治疗后早期乳腺癌门诊患者压力和情绪的影响
6. Docetaxel for the post-surgery treatment of patients with node-positive breast cancer [O] . Shubham Pant, Meena P Chilukuri, Bhuvaneswari Ramaswamy 2008

机译：多西紫杉醇用于淋巴结阳性乳腺癌患者的术后治疗
7. Cardiac safety results from a phase II, open-label, multicenter, pilot study of two docetaxel-based regimens plus bevacizumab for the adjuvant treatment of subjects with node-positive or high-risk node-negative breast cancer [O] . Sara A Hurvitz, Linda D Bosserman, David Chan, 2014

机译：心脏安全性来自II期，开放标签，多中心，两项基于多西他赛的方案加贝伐珠单抗对淋巴结阳性或高危淋巴结阴性乳腺癌患者的辅助治疗的初步研究

Docetaxel for the post-surgery treatment of patients with node-positive breast cancer

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